ZYCORTAL Suspension 4 ml

ZYCORTAL Suspension 4 ml
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List Price: $200.00
Sale Price: $145.00
Code: zycor4
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For dogs with Addison's disease, Zycortal® suspension is an injectable replacement therapy. Zycortal® is given subcutaneously in dogs with mineralocorticoid deficiency with primary hypoadrenocorticism.

For subcutaneous use in dogs only.

Mineralocorticoid.

Zycortal® Suspension is a white aqueous suspension. Each milliliter contains 25 mg of desoxycorticosterone pivalate. Inactive ingredients are 10.5 mg methylcellulose, 3 mg sodium carboxymethylcellulose, 1 mg polysorbate 60, 8 mg sodium chloride, 1 mg chlorocresol and water for injection (to 100%).

Zycortal® is made by Dechra. Dechra manufacturuers a number of therapy drugs for use in veterinary medicine. Some of the medications include Vetoryl, Levocrine, and Animax

DOSAGE AND ADMINISTRATION:

Prior to each use, thoroughly shake the vial to resuspend the product. ZYCORTAL® Suspension replaces the mineralocorticoid hormones only. Dogs with combined glucocorticoid and mineralocorticoid deficiency should also be treated with prednisone or prednisolone at an initial dosage of 0.2-0.4 mg/kg/day (0.1-0.2 mg/lb/day). ZYCORTAL® Suspension is intended for long-term administration at intervals and doses dependent upon individual response. Tailor the dose of ZYCORTAL® Suspension and the concurrently administered glucocorticoid replacement therapy to the individual dog based on clinical response and normalization of Na+ and K+ concentrations.

Initial dose of ZYCORTAL® Suspension:

The initial dose is 2.2 mg/kg (1 mg/lb) body weight, administered by subcutaneous injection.

Interim monitoring visit:

Re-evaluate the dog and measure the serum sodium/potassium ratio (Na+/K+ ratio) approximately 10 days after the first dose, which is the time to maximum concentration (Tmax ) of desoxycorticosterone (see CLINICAL PHARMACOLOGY). If the dog's clinical signs have worsened or not resolved, adjust the dose of prednisone/prednisolone and/or investigate other causes of the clinical signs.

Second dose of ZYCORTAL® Suspension:

At approximately 25 days after the first dose, re-evaluate the dog and repeat the Na+/K+ ratio.

  • If the dog is both clinically normal and has a normal Na+/K+ ratio on Day 25, adjust the dose based on the Day 10 Na+/K+ ratio using the guidelines in Table 1, below.
  • If the dog is clinically normal and has a Na+/K+ ratio > 32 on Day 25, either adjust the dose based on the Day 10 Na+/K+ ratio according to Table 1 or delay the dose (see Prolonging the dosing interval).
  • If the dog is either not clinically normal or if the Na+/K+ ratio is abnormal on Day 25, adjust the dose of prednisone/prednisolone or ZYCORTAL® Suspension (see Subsequent doses and long-term management).